Tribble Agency
Tribble Agency


Common Acid Reflux, Heartburn Medications May Increase Kidney Disease Risk

These new studies are the first to produce data that illustrate the effect of long-term PPI use. A Recent study revealed that these medications damage kidneys and may have adverse effects on the functioning of Kidneys. These drugs work by reducing the amount of acid produced in the stomach.

Kidney disease is the eighth leading cause of death in the United States, with an estimated 31 million people suffering from chronic kidney disease (CKD).

The findings of the studies will be presented to the annual meeting of the American Society of Nephrology, which will be held in San Diego, California from November 3-8.

There are a few medicines and treatments used to treat the heartburn and acidity.

In one of the new studies, Benjamin Lazarus, from Johns Hopkins University in Baltimore, MD, and colleagues followed 10,482 healthy adults from 1996-2011. Their findings showed that PPI users were 20 percent to 50 percent more likely to develop chronic kidney disease than those who did not take PPIs. This discovery was replicated in a second study, in which over 240,000 patients were followed from 1997 to 2014.

Led by Dr. Pradeep Arora of SUNY-Buffalo, researchers analyzed data from 99,351 patients who were seen in primary care clinics from April 2001 to April 2008; 27,835 patients with baseline CKD were excluded.

These types of medications are Proton Pump Inhibitors, and have been proven to be very effective at treating ulcers, reflux, and other heartburn conditions.

Two new studies suggest medications taken to relieve symptoms of acid reflux and heartburn may be linked to a higher risk of chronic kidney disease (CKD).

"In both studies, people who used a different class of medications to suppress stomach acid, known as H2-blockers, did not have a higher risk of developing kidney disease", Lazarus pointed out.

One out of four of the kidney patients had been previously treated using a PPI.

Among the total group of participants in the second study, Researchers did find a decreased risk of other health problems among PPI users, such as cancer and chronic obstructive pulmonary disease.

Chronic kidney disease is rising remarkably across the globe particularly in the Western nations.

The kidneys might become damaged over time if patients suffer repeated bouts of acute interstitial nephritis (a form of tissue inflammation), which has been linked with short-term use of PPIs, he said.

PPIs also can cause magnesium levels in the blood to decline.

"It is very reasonable to assume that PPIs themselves can cause chronic kidney disease". "We are using this medication right and left, and it may be counterproductive for many patients".

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